Cord blood stem cells expanded in the lab by modifying chromosome properties
Source: Published in Volume 124, Issue 6 (June 2, 2014) J Clin Invest. 2014;124(6):2378–2395. doi:10.1172/JCI70313 ; Link: http://www.jci.org/articles/view/70313?elq=b058892740e54a2589333bad4b0fa86e&elqCampaignId=12
The stem cells in cord blood that are responsible for reconstitution of the blood and immune system in the body have typically been difficult to “grow” in the laboratory. Hence smaller volume cord blood units are have less potential to be used. Recent research has demonstrated that treatment of these cells with histone deacetylase inhibitors (HDACIs), which affect a component of cellular chromosomes, increases this cell population. Chromosomal modification offers a new approach to expansion of the potentially life saving stem cell population within cord blood donations.